Unveiling MeNAP CX Catalyst Technology

A breakthrough in the realm of chemical reactions

At Umicore Precious Metals Chemistry, we leverage cutting-edge catalysts like MeNAP CX to transform cross-coupling reactions. MeNAP, or Di(µ-bromo)bis(1-methylnaphthyl)dipalladium(II), is a highly effective precatalyst, that works seamlessly with preferred ligands to enable very specific and selective coupling reactions.

Why MeNAP CX Catalysts matter

C-C-bond formation via cross-coupling catalysis stands as a cornerstone in organic chemistry. MeNAP CX catalysts facilitate the synthesis of biologically active or other important functional molecules and plays a key role in the development of target products.

At Umicore Precious Metals Chemistry, we recognize the importance of cross-coupling chemistry. Our commitment to advancing this field is reflected in our diverse CX catalyst portfolio. By incorporating MeNAP CX into Umicore’s portfolio, we ensure our customers have access to cutting-edge technology for their development needs.

Key Features of MeNAP CX Catalysts

The key feature of MeNAP CX lies in its ability to execute challenging cross-coupling reactions such as Suzuki-Miyaura couplings of arylchlorides and boronic acid derivatives forming tetra-ortho-substituted biaryls at room temperature with low catalyst loadings. Moreover, MeNAP CX catalysts can be combined flexibly with many different phosphine, NHC or Buchwald ligands to enable a fine-tuning of individual reactions and increasing the accessible substrate scope.

Driving Innovation Together

Umicore invites you to embark on a collaborative journey with us! You can take advantage of Umicore services such as screening support to explore how our MeNAP precursors M700 and M750 or preformed catalysts can address your unique challenges across pharmaceuticals, fine-chemicals, and beyond. We have selected few privileged phosphines and NHC ligands to allow a first screening of the technology. 

We also offer customization of MeNAP catalysts with your preferred ligands to create your own MeNAP CX technology success stories. We will be happy to evaluate any ligands you may identify in your screening tests to prepare preformed catalysts. So, you do not need to bother for catalyst preparation at scale. Our MeNAP technology is very versatile, and we are continuously evaluating more ligands.

Therefore, stay tuned!

Published articles on MeNAP (open access):

Palladium-Catalyzed γ-Arylation of Acylketene Synthons with Aryl Chlorides Enabled by Ylide-Functionalized Phosphines (YPhos). - Manna, S., Papp, F., Hisata, Y., Löffler, J., Rybka, M., Gessner, V.H., Hoshimoto, Y. and Gooßen, L.J. - Adv. Synth. Catal. 2024
(https://doi.org/10.1002/adsc.202301474)

Enantioselective Synthesis of Arylglycines via Pd-Catalyzed Coupling of Schöllkopf Bis-Lactim Ethers with Aryl Chlorides. - D. Sowa Prendes, F. Papp, N. Sankaran, N. Sivendran, F. Beyer, C. Merten, L. J. Gooßen - Angew. Chem. Int. Ed. 2023, e202309868.  
(https://doi.org/10.1002/anie.202309868)

Selective Monoarylation of Ammonium Triflate with Aryl Chlorides Catalyzed by [Pd(β-MeNAP)Br]2 and AdBrettPhos - B. Xue, J. Shen, S. Manna, A. Doppiu, L. J. Goossen - Adv. Synth. Catal. 2023, 365, 20, 3473-3477.  
(https://doi.org/10.1002/adsc.202300761)

Halogen-bridged Methylnaphthyl Palladium Dimers as Versatile Catalyst Precursors in Coupling Reactions - N. Sivendran, N. Pirkl, Z. Hu, A. Doppiu, L. J. Gooßen - Angew. Chem. Int. Ed. 2021, 68, 25151-25160.  
(https://doi.org/10.1002/anie.202110450)

Seeking more information about MeNAP's applications or its availability for your specific needs? Reach out to us! Our team is ready to provide tailored information, discuss potential collaborations, or answer any queries you might have regarding MeNAP technology.