MeNAP CX Catalysts
Pioneering advancements in chemical reaction catalysis
At Umicore PMC, we harness state-of-the-art catalysts such as MeNAP CX to revolutionize cross-coupling reactions. MeNAP, also known as Di(µ-bromo)bis(1-methylnaphthyl)dipalladium(II), acts as an exceptionally fast activating precatalyst. It collaborates seamlessly with cutting-edge ligand technology, facilitating precise and selective coupling reactions.
Key Features of the MeNAP CX Catalysts:
- Specialized in executing challenging cross-coupling reactions like Suzuki-Miyaura couplings
- Able to facilitate the formation of tetra-ortho-substituted biaryls at room temperature
- Achieves this with low catalyst loadings, enhancing efficiency
- Offers flexibility by combining with various phosphine, NHC, or Buchwald ligands
- Allows fine-tuning for individual reactions, expanding the range of accessible substrates
- Enhances substrate scope by adapting to different ligands, broadening applicability
Di(µ-bromo)bis(1-methylnaphthyl)dipalladium(II)
CAS Number: 2751616-98-3
Empirical formula: [Pd(α-MeNAP)Br]2
- Synthesis of challenging tetra-ortho-substituted arenes
- Use of arylchlorides
- Up to quantitative yields achievable at rt
- Low catalyst loading
1-Methylnaphthyl[tris(tert-butyl)phosphine]bromopalladium(II)
CAS Number: 2751617-01-1
Empirical formula: Pd(α-MeNAP)(P(tBu)3)Br
1-Methylnaphthyl[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]bromopalladium(II)
CAS Number: 2751617-04-4
Empirical formula: Pd(α-MeNAP)(IPr)Br
1-Methylnaphthyl[bis-(1-adamantyl)butyl]bromopalladium(II)
CAS Number: 2751617-11-3
Empirical formula: Pd(α-MeNAP)(cataCXium® A)Br
Di(µ-bromo)bis(2-methylnaphthyl)dipalladium(II)
CAS Number: 2751617-00-0
Empirical formula: [Pd(β-MeNAP)Br]2
- Comparable performance and substrate scope as CX700 (Suzuki-Miyaura)
- Outstanding performance in the monoarylation of ammonium triflate
- Use in late-stage functionalization of substituted anilines
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