Olefin Metathesis for constrained peptide synthesis
Olefin metathesis offers new opportunities in the synthesis of constrained peptides. At Umicore Precious Metals Chemistry, we support peptide innovators in exploring metathesis as a complementary synthetic tool to access novel peptide architectures and address emerging development challenges.
Expanding the design space for the next‑generation of peptides
Why consider metathesis in peptide synthesis?
Access new structural possibilities
Macrocyclic ring-closing metathesis can be used to introduce defined constraints into peptide structures, supporting the development of peptides with enhanced stability and functionality.
Broaden your synthetic toolbox with a powerful C-C bond forming reaction with excellent bio-orthogonality
For teams looking beyond established peptide chemistry approaches, metathesis provides an additional option to explore alternative routes and architectures.
Build on existing expertise
Pharmaceutical organizations already familiar with metathesis in small‑molecule synthesis may find valuable synergies when evaluating its application in peptide chemistry.
How Umicore supports your exploration
Application‑focused expertise
We bring deep scientific understanding of macrocyclic ring-closing metathesis (mRCM) and its role in constrained peptide synthesis, grounded in our decades of combined experience in scaling olefin metathesis reactions.
Early‑stage technical discussions
We support exploratory conversations to assess feasibility, identify potential use cases, and discuss practical considerations - without predefined solutions.
State of the art metathesis catalyst portfolio
A lot has changed since the first metathesis catalyst was reported more than 3 decades ago! Our comprehensive portfolio of Grubbs Catalyst® technologies was developed over many years to meet our customers' specific metathesis needs.
Is this relevant for you?
This topic may be of interest if you:
- Work on constrained, macrocyclic, or stapled peptides
- Are curious about metathesis, but have limited experience in peptide applications
- Use metathesis in small‑molecule chemistry and want to assess its relevance for peptides
- Are evaluating new synthetic strategies to differentiate peptide candidates
If your target scale is between a nanogram and a kiloton, we can help!