CAS Number: 192139-92-7
Product class: M-N, Homogeneous Catalysts, M-C, Arene/Aryl Ligands, Chiral Ligands
Reaction type: Hydrogenation, Asymmetric Reactions, Asymmetric Hydrogenation, Transfer Hydrogenation
Applications & references
Synthesis of optically active 4-hydroxy-2,6,6-trimethyl-cyclohex-3-enone derivatives via enantioselective transfer hydrogenation of the corresponding enolethers for the production of (3S,3’S)-astaxantin.
Reference: WO2008 116714
Asymmetric transfer hydrogenation of functionalized ketones for the drug substance synthesis, e.g. rivastigimine for the treatment of Alzheimer’s disease.
Reference: WO2010 0072798
Preparation of optically active aromatic epoxides by asymmetric transfer hydrogenation of α-chlorinated ketones.
Reference: Tetrah. 2004, 60, 7411 (DOI: 10.1016/j.tet.2004.06.076)
Asymmetric transfer hydrogenation of benzyl with formic acid.
Reference: Org. Lett. 1999, 1, 1119 (DOI: 10.1021/ol990226a)