hAPIs and catalysis for a better quality of life

Proper active pharmaceutical ingredient (API) selection is crucial to many medicinal products and to fulfill these needs, we offer an array of catalysts.

Whether you’re a highly potent anti-cancer drug manufacturer or your challenge is ring closure metathesis for your large member ring, palladium chemistry for your amination reaction or your need is a homogeneous catalyst, we have your solution.

high potency APIs manufacturing

Reliable partner, reliable quality

Umicore has been producing and marketing high potency APIs (hAPIs) for more than 20 years – complying with cGMP requirements, ICH guidelines and all applicable regulations in the pharmaceutical industry.

Opened in 2009 in Buenos Aires, Argentina, our state-of-the-art hAPI facility produces in compliance with cGMP requirements for global markets. The facility has been inspected and endorsed by a variety of health agencies and customers. In 2014, an independent, third-party audit in accordance with DIN/ISO14001 norms verified the facility's high standards and in 2016 it underwent a successful inspection by the USFDA.

Managed under European standards and values, the Argentinian site offers our customers an advantageous cost competitiveness as well as unique and innovative options to develop launch strategies for generic molecules.

We also offer exclusive contract development services at our dedicated R&D group in Hanau-Wolfgang, Germany. Our expertise spans from extensive synthesis and manufacturing to specialized intellectual property (IP) and regulatory affairs support.

Major process development and manufacturing competencies include:

  • Inorganic, organic, precious metal based and organometallic chemistry
  • Processing of highly pure, sensitive, toxic or pyrophoric materials
  • Process development and manufacturing in high containment facilities (OEB5)
  • Integrated analytics expertise

Exclusive synthesis services include:

  • Dedicated project management under strict confidentiality and IP control
  • Customized support from pre-clinical development to commercial phase
  • Non-GMP development labs
  • cGMP manufacturing facility
  • In-house QA and QC expertise and services
  • Global IP strategy support
  • Specialized regulatory affairs team

Contact us to start talk about our next development or supply cooperation.

Related products

Catalysts for fine chemicals and intermediates manufacturing

Health matters to us.

We value customer collaboration because you know your business best. Our long-term collaborative approach to R&D and commercial manufacturing makes your innovative drug compounds come to life.

Catalyst screening services:

Pharmaceutical companies face increasing pressure to enhance R&D productivity while facing challenging molecular targets. As a result of the recent integration of Grubbs CatalystTM Technology to our portfolio, we can now offer screening services enabling you to leverage on our leading expertise in advanced catalyst technologies, spanning from metathesis to stereoselective hydrogenation or cross-coupling. Contact us to test the efficiency and flexibility of our screening services.

Process development support:

Our technical team has extensive understanding of the key parameters to successfully scale up a homogeneously catalysed reaction. We closely work with you and provide all technical support possible to help you develop a robust process in aggressive timeframes.

Now including Grubbs CatalystTM Technology.

Umicore Grubbs CatalystTM Technology has been instrumental in the discovery of several new pharmaceutical breakthroughs. With the integration of Materia's metathesis catalyst business, Umicore's olefin metathesis technology forms a unique tool for the construction of new scaffolds with high sp3 content and 3D character including macrocycles and spirocycles. Our scientists are experts at applying metathesis and are available to help development chemists plan reaction conditions that will be successful.

The combination of our novel homogeneous catalysts, our innovative approach to metal based chemistry, our flexible commercial scale manufacturing and our metal recycling expertise give you a solid foundation upon which to develop and manufacture your high value chemical intermediates in the most sustainable manner – anywhere in Europe, the Americas or Asia.

Whether your synthesis embeds an olefin metathesis step, a selective cross-coupling reaction or a stereoselective hydrogenation, we have the solution.

Related products
We use cookies on our website. To learn more about cookies, how we use them, and how to change your cookie settings, please read our Terms of Use and Privacy and Cookie Policy. By accepting, you consent to the Terms and the Policy.

Necessary Cookies
Necessary Cookies are Cookies that are required for the Website to operate as intended by Umicore. Necessary Cookies do not identify you as an individual and, if you do not accept them, then some features of the Website may not function properly.
Analytical Cookies
Analytical Cookies are Cookies that help Umicore improve the Website by collecting User Data. Analytical Cookies do not identify you as an individual and all User Data that is collected by Analytical Cookies is aggregated and anonymous.