CAS Number: 887919-35-9
Product class: M-P, Homogeneous Catalysts, Monodentate Ligands, Phosphorus Ligands - Achiral
Reaction type: Cross Coupling Reactions with Arenes, Suzuki-Miyaura Coupling Reaction
Applications & references
Synthesis of the pyrazolopyridinone-based p38 mitogen-activated protein kinase inhibitor including a Suzuki coupling reaction. p38 MAP kinases are intercellular serine/threonine kinases which certainly regulate the production and action of several pro-inflammatory mediators. They are also involved in disease states such as rheumatoid arthritis, Crohn’s diseases and psoriasis.
Reference: Org. Proc. Res. Dev. 2011, 15, 31. (DOI: 10.1021/op100205s)