Umicore CX84

Umicore CX84

Dichlorobis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II)

CAS Number: 887919-35-9

Product class: Homogeneous Catalysts, M-P, Monodentate Ligands, Phosphorus Ligands - Achiral

Reaction type: Cross Coupling Reactions with Arenes, Suzuki-Miyaura Coupling Reaction

Chemical properties
Chemical formula

C32H56N2Cl2P2Pd

Empirical formula

[Pd(amphos)2Cl2]

Molecular weight

708.08

Metal

Pd

Theoretical metal content

15

Physical state

powder

Color

yellow

Metal purity

99.95

Applications & references

Synthesis of the pyrazolopyridinone-based p38 mitogen-activated protein kinase inhibitor including a Suzuki coupling reaction. p38 MAP kinases are intercellular serine/threonine kinases which certainly regulate the production and action of several pro-inflammatory mediators. They are also involved in disease states such as rheumatoid arthritis, Crohn’s diseases and psoriasis.

Reference: Org. Proc. Res. Dev. 2011, 15, 31. (DOI: 10.1021/op100205s)

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