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Business unit / dept.: Precious Metals Chemistry

Umicore CX84

Umicore CX84

Dichlorobis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II)

CAS Number: 887919-35-9

Chemical properties

Chemical formula

C32H56N2Cl2P2Pd

Empirical formula

[Pd(amphos)2Cl2]

Molecular weight

708.08

Metal

Pd

Theoretical metal content

15

Physical state

powder

Color

yellow

Metal purity

99.95

Your contact person

Yukari Nakada

T: +81 90 9018 6731
Email

Heidi Heuser

T: +49 6181 706 4787
Email

Don Zeng

T: +1 (714) 777 3737
Email

Chinmay Pandya

T: +91 9867662944
Email

Heidi Heuser

T: +49 6181 706 4787
Email

Applications & references

Description

Synthesis of the pyrazolopyridinone-based p38 mitogen-activated protein kinase inhibitor including a Suzuki coupling reaction. p38 MAP kinases are intercellular serine/threonine kinases which certainly regulate the production and action of several pro-inflammatory mediators. They are also involved in disease states such as rheumatoid arthritis, Crohn’s diseases and psoriasis.

Reference: Org. Proc. Res. Dev. 2011, 15, 31. (DOI: 10.1021/op100205s)

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