Umicore CX73
Umicore CX73
Dichlorobis(triphenylphosphine)palladium(II)
CAS Number: 13965-03-2
Applications & references
Description
Synthesis of the pyrazolopyridinone-based p38 mitogen-activated protein kinase inhibitor including a Suzuki coupling reaction. p38 MAP kinases are intercellular serine/threonine kinases which certainly regulate the production and action of several pro-inflammatory mediators. They are also involved in disease states such as rheumatoid arthritis, Crohn’s diseases and psoriasis.
Reference: Org. Proc. Res. Dev. 2011, 15, 31. (DOI: 10.1021/op100205s)
Mild and effective direct palladium catalyzed C-H alkynylation of electron-rich heterocycles.
Reference: J. Am. Chem. Soc. 2007, 129, 7742. (DOI: 10.1021/ja072718l)
Synthesis of spiro-indane-oxindoles with a tandem Heck / C-H functionalization.
Reference: Angew. Chem. Int. Ed. 2008, 47, 4711. (DOI: 10.1002/anie.200800549)
Palladium catalyzed intermolecular decarboxylative coupling in the presence of reactive C-H groups.
Reference: J. Org. Chem. 2010, 75, 1550. (DOI: 10.1021/jo9022793)
High yielding Palladium catalyzed C-H arylation of electron-enriched heteroarenes with aryl bromides.
Reference: J. Org. Chem. 2010, 75, 6998. (DOI: 10.1021/jo101433g)
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