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Business unit / dept.: Precious Metals Chemistry

Umicore CX73

Umicore CX73

Chemical properties

Chemical formula

C36H30Cl2P2Pd

Empirical formula

[Pd(PPh3)2Cl2]

Molecular weight

701.91

Metal

Pd

Theoretical metal content

15

Physical state

powder

Color

yellow

Metal purity

99.95

Applications & references

Description

Synthesis of the pyrazolopyridinone-based p38 mitogen-activated protein kinase inhibitor including a Suzuki coupling reaction. p38 MAP kinases are intercellular serine/threonine kinases which certainly regulate the production and action of several pro-inflammatory mediators. They are also involved in disease states such as rheumatoid arthritis, Crohn’s diseases and psoriasis.

Reference: Org. Proc. Res. Dev. 2011, 15, 31. (DOI: 10.1021/op100205s)

 

Mild and effective direct palladium catalyzed C-H alkynylation of electron-rich heterocycles.

Reference: J. Am. Chem. Soc. 2007, 129, 7742. (DOI: 10.1021/ja072718l)

 

Synthesis of spiro-indane-oxindoles with a tandem Heck / C-H functionalization.

Reference: Angew. Chem. Int. Ed. 2008, 47, 4711. (DOI: 10.1002/anie.200800549)

 

Palladium catalyzed intermolecular decarboxylative coupling in the presence of reactive C-H groups.

Reference: J. Org. Chem. 2010, 75, 1550. (DOI: 10.1021/jo9022793)

 

High yielding Palladium catalyzed C-H arylation of electron-enriched heteroarenes with aryl bromides.

Reference: J. Org. Chem. 2010, 75, 6998. (DOI: 10.1021/jo101433g)