Chiralyst® Ru636

Applications & references

Description

Synthesis of optically active 4-hydroxy-2,6,6-trimethyl-cyclohex-3-enone derivatives via enantioselective transfer hydrogenation of the corresponding enolethers for the production of (3S,3’S)-astaxantin.

Reference: WO2008 116714

Asymmetric transfer hydrogenation of functionalized ketones for the drug substance synthesis, e.g. rivastigimine for the treatment of Alzheimer’s disease.

Reference: WO2010 0072798

Preparation of optically active aromatic epoxides by asymmetric transfer hydrogenation of α-chlorinated ketones.  

Reference: Tetrah. 2004, 60, 7411 (DOI: 10.1016/j.tet.2004.06.076)

Asymmetric transfer hydrogenation of benzyl with formic acid.

Reference: Org. Lett. 1999, 1, 1119 (DOI: 10.1021/ol990226a)