Chiralyst Rh640

[((S,S)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

CAS Number: 219944-99-7

Product class:

Reaction type:

Chemical properties

Chemical formula

C₃₁H₃₆N₂ClO₂SRh

Empirical formula

Rh[(S,S)-TsDPEN](C₅Me₅)Cl

Molecular weight

639.06

Metal

Theoretical metal content

Physical state

crystalline

Color

orange brown

Metal purity

99.95

Applications & references

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Reference: WO2008 054155

Transfer hydrogenation of aromatic ß-ketoester for the synthesis of secondary aminoalcohols.

Reference: WO2005 028437

Asymmetric transfer hydrogenation of N-sulfonyl ketimine derivatives.

Reference: Tetrah. Asym. 2010, 21, 800 (DOI: 10.1016/j.tetasy.2010.04.047)

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanones derivatives leading to an efficient synthetic route of ß-adrenergic agonists.

Reference: Tetrah. Asym. 2007, 18, 2662 (DOI: 10.1016/j.tetasy.2007.10.046)

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Your contact person

Horiguchi Yoshiaki

T: +81 (3) 6685 3069

Xiaofang Bi

T: +86 (21) 2411 6870

Heidi Heuser

T: +49 (6181) 59 2413

Chinmay Pandya

T: +91 (22) 6627 5656

Phil Chalabi

T: +1 (918) 266 4826

Heidi Heuser

T: +49 (6181) 59 2413

Chiralyst Rh640

Chiralyst Rh640

[((S,S)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

Chemical properties

Applications & references

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Transfer hydrogenation of aromatic ß-ketoester for the synthesis of secondary aminoalcohols.

Asymmetric transfer hydrogenation of N-sulfonyl ketimine derivatives.

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanones derivatives leading to an efficient synthetic route of ß-adrenergic agonists.

Request a quote or MSDS

Your contact person

Horiguchi Yoshiaki

Xiaofang Bi

Heidi Heuser

Chinmay Pandya

Phil Chalabi

Heidi Heuser

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