Chiralyst® Rh639

[((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

CAS Number: 223392-99-2

Your contact person

Yukari Nakada

T: +81 90 9018 6731

Heidi Heuser

T: +49 6181 706 4787

Don Zeng

T: +1 (714) 777 3737

Chinmay Pandya

T: +91 9867662944

Heidi Heuser

T: +49 6181 706 4787

Applications & references

Description

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Reference: WO2008 054155

Asymmetric synthesis of ß-amino alcohols by rhodium catalyzed transfer hydrogenation of α-keto imines.

Reference: Tetrah. Asym. 2010, 21, 2244 (DOI: 10.1016/j.tetasy.2010.07.004)

One pot synthesis of sterically active epoxides starting from α-chloroacetophenones including a asymmetric transfer hydrogenation step.

Reference: Tetrah. 2004, 60, 7411 (DOI: 10.1016/j.tet.2004.06.076)

Synthesis of optically active styrene oxides by asymmetric reduction of 2-chloroacetophenones.

Reference: Org. Lett. 2002, 4, 4373 (DOI: 10.1021/ol020213o)

Enantioselective preparation of cyclic sulfamidates by using asymmetric transfer hydrogenation.

Reference: Org. Lett. 2010, 12, 4184 (DOI: 10.1021/ol1017905)

Asymmetric transfer hydrogenation of α-aminoalkyl α’-chloromethylketones yielding useful intermediates for the total synthesis of inhibitors of HIV protease and ß-secretase in Alzheimer disease.

Reference: J. Org. Chem. 2004, 69, 7391 (DOI: 10.1021/jo0491455)

Chiralyst® Rh639

Chiralyst® Rh639

[((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

Chemical properties

Your contact person

Yukari Nakada

Heidi Heuser

Don Zeng

Chinmay Pandya

Heidi Heuser

Applications & references

Description

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Asymmetric synthesis of ß-amino alcohols by rhodium catalyzed transfer hydrogenation of α-keto imines.

One pot synthesis of sterically active epoxides starting from α-chloroacetophenones including a asymmetric transfer hydrogenation step.

Synthesis of optically active styrene oxides by asymmetric reduction of 2-chloroacetophenones.

Enantioselective preparation of cyclic sulfamidates by using asymmetric transfer hydrogenation.

Asymmetric transfer hydrogenation of α-aminoalkyl α’-chloromethylketones yielding useful intermediates for the total synthesis of inhibitors of HIV protease and ß-secretase in Alzheimer disease.

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