Chiralyst® Rh640

[((S,S)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

CAS Number: 219944-99-7

Your contact person

Yukari Nakada

T: +81 90 9018 6731

Chinmay Pandya

T: +91 9867662944

Don Zeng

T: +1 (714) 777 3737

Heidi Heuser

T: +49 6181 706 4787

Ula Rao

T: +86 (21) 2411 6843

Heidi Heuser

T: +49 6181 706 4787

Applications & references

Description

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Reference: WO2008 054155

Transfer hydrogenation of aromatic ß-ketoester for the synthesis of secondary aminoalcohols.

Reference: WO2005 028437

Asymmetric transfer hydrogenation of N-sulfonyl ketimine derivatives.

Reference: Tetrah. Asym. 2010, 21, 800 (DOI: 10.1016/j.tetasy.2010.04.047)

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanones derivatives leading to an efficient synthetic route of ß-adrenergic agonists.

Reference: Tetrah. Asym. 2007, 18, 2662 (DOI: 10.1016/j.tetasy.2007.10.046)

Chiralyst® Rh640

Chiralyst® Rh640

[((S,S)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

Chemical properties

Your contact person

Yukari Nakada

Chinmay Pandya

Don Zeng

Heidi Heuser

Ula Rao

Heidi Heuser

Applications & references

Description

Asymmetric reduction of α-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Transfer hydrogenation of aromatic ß-ketoester for the synthesis of secondary aminoalcohols.

Asymmetric transfer hydrogenation of N-sulfonyl ketimine derivatives.

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanones derivatives leading to an efficient synthetic route of ß-adrenergic agonists.

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