Pd-Tetrakis

Pd-Tetrakis

Tetrakis(triphenylphosphine)palladium(0)

CAS Number: 14221-01-3

Product class: M-P, Homogeneous Catalysts, Monodentate Ligands, Phosphorus Ligands - Achiral

Reaction type: Cross Coupling Reactions with Arenes, Amination, Buchwald-Hartwig Aminaton, Carbonylation, Hiyama Coupling Reaction, Mizoroki Heck Coupling Reaction, Negishi Coupling Reaction, Sonogashira-Hagihara Coupling Reaction, Stille Reaction, Suzuki-Miyaura Coupling Reaction, Cyclization, Isomerization, Oxidation, Reduction

Chemical properties

Chemical formula

C72H60P4Pd

Empirical formula

[Pd(PPh3)4]

Molecular weight

1155.58

Metal

Pd

Theoretical metal content

9

Physical state

crystalline

Color

yellow

Metal purity

99.95

Applications & references

Suzuki coupling reaction as key synthesis step in the preparation of the chiral, nonracemic 3-aryl piperidine (OSU 6162), a potential central nervous system agent.

Reference: Org. Proc. Res. Dev. 2003, 7, 385. (DOI: 10.1021/op025620u)

 

Aryl-aryl Negishi coupling reaction in the preparation of 5-[2-Methoxy-5-(4-pyridinyl)phenyl]-2,1,3-benzoxadiazole (PDE472), a selective inhibitor of the phosphodiesterase PDE4D isoenzyme, which is well known as drug target for the treatment of asthma.

Reference: Org. Proc. Res. Dev. 2003, 7, 436. (DOI: 10.1021/op025615q)

 

Palladium catalyzed synthesis of trans-1,2-diazetidines by cyclization of 2,3-allenyl hydrazines with aryl halides.

Reference: Angew. Chem. Int. Ed. 2008, 47, 4581. (DOI: 10.1021/anie.200800364)

 

Palladium catalyzed cross coupling reaction of α-diazocarbonyl compounds with arylboronic acids providing access to α-aryl substituted α,β-unsaturated carbonyl compounds.

Reference: J. Am. Chem. Soc. 2008, 130, 1566. (DOI: 10.1021/ja0782293)

 

Palladium catalyzed intermolecular decarboxylative coupling in the presence of reactive C-H groups.

Reference: J. Org. Chem. 2010, 75, 1550. (DOI: 10.1021/jo9022793)

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