Chiralyst Rh640

Chiralyst Rh640

[((S,S)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](chloro)pentamethylcyclopentadienylrhodium(I)

CAS Number: 219944-99-7

Product class: Homogeneous Catalysts, M-C, Arene/Aryl Ligands, M-N, Chiral Ligands

Reaction type: Asymmetric Reactions, Hydrogenation, Asymmetric Hydrogenation, Transfer Hydrogenation

Chemical properties
Chemical formula

C31H36N2ClO2SRh

Empirical formula

Rh[(S,S)-TsDPEN](C5Me5)Cl

Molecular weight

639.06

Metal

Rh

Theoretical metal content

16

Physical state

crystalline

Color

orange brown

Metal purity

99.95

Applications & references

Asymmetric reduction of a-sulfonyloxy acetophenone compound yielding an optically active 2-sulfonyloxy-1-phenylethanol derivative with high enantiomer excess.

Reference: WO2008 054155

Transfer hydrogenation of aromatic ß-ketoester for the synthesis of secondary aminoalcohols.

Reference: WO2005 028437

Asymmetric transfer hydrogenation of N-sulfonyl ketimine derivatives.

Reference: Tetrah. Asym. 2010, 21, 800 (DOI: 10.1016/j.tetasy.2010.04.047)

Asymmetric transfer hydrogenation of 2-tosyloxy-1-(4-hydroxyphenyl)ethanones derivatives leading to an efficient synthetic route of ß-adrenergic agonists.

Reference: Tetrah. Asym. 2007, 18, 2662 (DOI: 10.1016/j.tetasy.2007.10.046)

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