Umicore Grubbs Catalyst M101

Umicore Grubbs Catalyst M101

Dichloro(3-phenyl-1H-inden-1-ylidene)bis(tricyclohexylphosphine)ruthenium(II)

CAS Number: 250220-36-1

Product class: Homogeneous Catalysts, Grubbs Catalyst® 1st Generation, M-P, Phosphorus Ligands - Achiral

Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis

Chemical properties
Chemical formula

C51H76Cl2P2Ru

Empirical formula

Ru(PCy3)2(Ind)Cl2

Molecular weight

923.08

Metal

Ru

Theoretical metal content

11

Physical state

powder

Color

brown

Metal purity

99.95

Legal information

WO 2010 037550 and WO 2014 001291 apply.

Applications & references

Total synthesis of macrocyclic HCV protease inhibitor with RCM as key step.

Reference: US2009 0163706

Metathesis key step in the synthesis of cyclic tripyrole pigment nonylprodigiosin.

Reference: J. Org. Chem. 1999, 64, 8275 (DOI: 10.1021/jo991021i)

Total synthesis of macrocyclic compounds which are useful as inhibitors of hepatitis C virus N33 protease.

Reference: US2007 0027071

Macrocyclization step by ring closing metathesis in the synthesis of turrianes.

Reference: Chem. Eur. J. 2002, 8, 1856 (10.1002/1521-3765(20020415)8:8<1856::AID-CHEM1856>3.0.CO;2-RView)

Ring closing metathesis.   

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)                         

Enyne cycloisomerization.    

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)  

Nucleophilic addition of acids to alkynes.

 

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B) 

Diastereoselective double ring closing metathesis.

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B) 

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