Umicore Grubbs Catalyst M101

Dichloro(3-phenyl-1H-inden-1-ylidene)bis(tricyclohexylphosphine)ruthenium(II)

CAS Number: 250220-36-1

Product class: Homogeneous Catalysts, Grubbs Catalyst® 1st Generation, M-P, Phosphorus Ligands - Achiral

Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis

Legal information

WO 2010 037550 and WO 2014 001291 apply.

Applications & references

Total synthesis of macrocyclic HCV protease inhibitor with RCM as key step.

Reference: US2009 0163706

Metathesis key step in the synthesis of cyclic tripyrole pigment nonylprodigiosin.

Reference: J. Org. Chem. 1999, 64, 8275 (DOI: 10.1021/jo991021i)

Total synthesis of macrocyclic compounds which are useful as inhibitors of hepatitis C virus N33 protease.

Reference: US2007 0027071

Macrocyclization step by ring closing metathesis in the synthesis of turrianes.

Reference: Chem. Eur. J. 2002, 8, 1856 (10.1002/1521-3765(20020415)8:8<1856::AID-CHEM1856>3.0.CO;2-RView)

Ring closing metathesis.   

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)                         

Enyne cycloisomerization.    

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)  

Nucleophilic addition of acids to alkynes.

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B) 

Diastereoselective double ring closing metathesis.

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)