Umicore Grubbs Catalyst M101
Umicore Grubbs Catalyst M101
Dichloro(3-phenyl-1H-inden-1-ylidene)bis(tricyclohexylphosphine)ruthenium(II)
CAS Number: 250220-36-1
Product class: M-P, Homogeneous Catalysts, Grubbs Catalyst® 1st Generation, Phosphorus Ligands - Achiral
Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis
Legal information
WO 2010 037550 and WO 2014 001291 apply.
Applications & references
Total synthesis of macrocyclic HCV protease inhibitor with RCM as key step.
Reference: US2009 0163706
Metathesis key step in the synthesis of cyclic tripyrole pigment nonylprodigiosin.
Reference: J. Org. Chem. 1999, 64, 8275 (DOI: 10.1021/jo991021i)
Total synthesis of macrocyclic compounds which are useful as inhibitors of hepatitis C virus N33 protease.
Reference: US2007 0027071
Macrocyclization step by ring closing metathesis in the synthesis of turrianes.
Reference: Chem. Eur. J. 2002, 8, 1856 (10.1002/1521-3765(20020415)8:8<1856::AID-CHEM1856>3.0.CO;2-RView)
Ring closing metathesis.
Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)
Enyne cycloisomerization.
Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)
Nucleophilic addition of acids to alkynes.
Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)
Diastereoselective double ring closing metathesis.
Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)