Umicore Grubbs Catalyst M101

Umicore Grubbs Catalyst M101


CAS Number: 250220-36-1

Product class: M-P, Homogeneous Catalysts, Grubbs Catalyst® 1st Generation, Phosphorus Ligands - Achiral

Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis

Chemical properties

Chemical formula


Empirical formula


Molecular weight




Theoretical metal content


Physical state




Metal purity


Legal information

WO 2010 037550 and WO 2014 001291 apply.

Applications & references

Total synthesis of macrocyclic HCV protease inhibitor with RCM as key step.

Reference: US2009 0163706


Metathesis key step in the synthesis of cyclic tripyrole pigment nonylprodigiosin.

Reference: J. Org. Chem. 1999, 64, 8275 (DOI: 10.1021/jo991021i)


Total synthesis of macrocyclic compounds which are useful as inhibitors of hepatitis C virus N33 protease.

Reference: US2007 0027071


Macrocyclization step by ring closing metathesis in the synthesis of turrianes.

Reference: Chem. Eur. J. 2002, 8, 1856 (10.1002/1521-3765(20020415)8:8<1856::AID-CHEM1856>3.0.CO;2-RView)


Ring closing metathesis.   

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)


Enyne cycloisomerization.    

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)


Nucleophilic addition of acids to alkynes.

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B)


Diastereoselective double ring closing metathesis.

Reference: Chem. Comm. 2008, 2726 (DOI: 10.1039/B718287B) 

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Your contact person

Horiguchi Yoshiaki

T: +81 (3) 6685 3069

Xiaofang Bi

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Heidi Heuser

T: +49 (6181) 59 2413

Chinmay Pandya

T: +91 (22) 6627 5656

Heidi Heuser

T: +49 (6181) 59 2413

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